Genética y epigenética: yo soy yo y mi circunstancia

• Carlos Vicente Córdoba ^[1]
  1. [1] Universidad Complutense de Madrid

     Universidad Complutense de Madrid

     Madrid, España

     
• Localización: Boletín de la Real Academia de Córdoba de Ciencias, Bellas Letras y Nobles Artes, ISSN 0034-060X, Vol. 96, Nº. 166, 2017, págs. 33-51
• Idioma: español
• Enlaces
  • Texto completo (pdf)
• Resumen
  • español

    El fondo científico de la frase de Ortega y Gasset “yo soy yo y mi circunstancia” fue aclarado por Waddington, al definir la Epigenética como el estudio de las interacciones causales entre los genes y sus productos que dan lugar al fenotipo. Dicho de otra forma, durante el desarrollo y el ciclo vital de cada individuo pueden darse cambios heredables en la función génica que se producen sin un cambio en la secuencia del DNA.

    Estos cambios consisten en modificaciones del DNA, modificaciones de las histonas y producción de RNAs no mensajeros y, por tanto, no codificantes y afectan al desarrollo emocional del individuo, al desarrollo de los centros cerebrales encargados de la percepción, la memoria, las relaciones causa-efecto y la gestión de las emociones, por lo que condicionan la personalidad final del individuo.

  • English

    The scientific background of Ortega y Gasset's phrase "I am me and my circumstance" was clarified by Waddington, when defines Epigenetics as the study of causal interactions between genes and their products that give rise to the phenotype. In other words, there may be inheritable changes in gene function that occur without a change in DNA sequence during the development and life cycle of each individual.

    These changes consist of DNA and histone modifications and production of non-messenger, non-coding RNAs that affect the individual's emotional development, the development of brain centers responsible for perception, memory, relationships cause-effect and management of emotions, so they condition the individual's final personality

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