This article proposes that ekphrases in the Libro de Alexandre allude to Emperor Frederick II’s offences against the papacy, as well as a corpus of pro-papal hierocratic texts. Through comparative readings of Pope Innocent III’s decretal ‘In Genesi legimus’ and selected works of Honorius Augustodunensis, I argue that Stateira’s tomb should be interpreted according to the hierocratic mode of biblical exegesis, which utilizes the four senses of scripture to endow biblical episodes with hierocratic connotations, thereby enabling the tomb to be read as an allegory of arguments for papal primacy in imperial affairs.